Malaria and the Sickling Trait
نویسندگان
چکیده
منابع مشابه
The relationship of serum gamma-globulin concentration to malaria and sickling.
The serum protein patterns of groups of Nigerians including 98 children partially protected by "daraprim" against malaria, and 113 unprotected children, have been studied. The protected children have a significantly lower concentration of serum gamma globulin than the unprotected children from the age of 12 months onwards. In children, sicklers have a significantly higher serum gamma globulin t...
متن کاملEffects of a single sickling event on the mechanical fragility of sickle cell trait erythrocytes.
Hemolysis contributes to the pathology associated with sickle cell disease. However, the mechanism of hemolysis or relative contribution of sickling due to hemoglobin (Hb) polymerization vs. oxidative damage remains unknown. Earlier studies aimed at deciphering the relative importance of these two mechanisms have been complicated by the fact that sickle red cells (SS) have already been affected...
متن کاملProtection against malaria by sickle-cell trait.
We have shown that the haemolytic activity of fatty acids may be implicated in the destruction of erythrocytes by malaria parasites (Laser et al., 1975a,b). Under normal conditions free fatty acids are buffered by albumin in the serum and haemoglobin within the erythrocyte. During a malarial infection, however, the presence of the Plasmodium leads to an increase in both serum and erythrocyte fa...
متن کاملGBT440 Inhibits Sickling of Sickle Cell Trait Blood Under In Vitro Conditions Mimicking Strenuous Exercise
In sickle cell trait (SCT), hemoglobin A (HbA) and S (HbS) are co-expressed in each red blood cell (RBC). While homozygous expression of HbS (HbSS) leads to polymerization and sickling of RBCs resulting in sickle cell disease (SCD) characterized by hemolytic anemia, painful vaso-occlusive episodes and shortened life-span, SCT is considered a benign condition usually with minor or no complicatio...
متن کاملExertional sickling: questions and controversy
Sickle cell trait (SCT) occurs in about 8% of African-Americans and is often described to be of little clinical consequence. Over time, a number of risks have emerged, and among these are rare but catastrophic episodes of sudden death in athletes and other individuals associated with physical activities which is often described as exercise collapse associated with sickle trait (ECAST). Despite ...
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ژورنال
عنوان ژورنال: BMJ
سال: 1955
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.1.4923.1186